Watch NBC Nightly News with Lester Holt every Tuesday for our Snapshot – unique stories of talented and passionate Americans. | NBC Nightly News with Tom Llamas

"One pill could kill. One pill, one time, game over." Tonight on NBC Nightly News, Lester Holt talks to Cheri Oz, Special Agent in Charge of the DEA's Phoenix Field Division, about the fentanyl crisis. Watch the full report at 6:30 pm ET / 5:30 pm CT (check local listings). | NBC Nightly News with Tom Llamas

Ahead for us on NBC Nightly News with Lester Holt: We'll have the latest on Covid booster shots and Lester Holt's interview with Dr. Anthony Fauci. Stephanie Ruhle reports on child care difficulties as Americans return to offices. And much more. Tune in at 6:30pm ET / 5:30pm CT (check local listings). | NBC Nightly News with Tom Llamas