The fate of pyruvate changes in accordance with our nutritional state. In the well-fed state, pyruvate can be covered to acetyl coA and further metabolized by the TCA cycle, or is converted to the non-essential amino acid alanine. During fasting, pyruvate is converted to either lactate or oxaloacetate. The latter molecules is the first step of gluconeogenesis in the liver intended to restore glucose to the bloodstream during fasting. #pyruvate #fasting #well -fed #biochemistry #MetabolismMadeEas
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Pyruvate derived from glycolysis has 4 distinct fates: 2 reversible fates which convert Pyruvate to alanine or lactate and 2 irreversible fates that convert pyruvate to oxaloacetate or acetyl CoA.The latter fates can contribute to either gluconeogenesis or the TCA cycle for energy production. #glycolysis #pyruvate #fates #biochemistry #MetabolismMadeEasy
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