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Long-term use of Proton Pump Inhibitors (PPIs) is linked to a higher risk of kidney damage through several potential pathways: ​Key Risks ​Acute Interstitial Nephritis (AIN): This is an immune-mediated reaction where the kidney tubules become inflamed. It is often "silent," meaning it can occur without obvious symptoms until significant damage is done. ​Chronic Kidney Disease (CKD): Observational studies suggest long-term users have a 20% to 50% higher risk of developing CKD compared to non-user
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