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0:17
YouTube
biolution
Afatinib inhibits EGFR Receptor activation
The animation shows a dimer of the intracellular domain of the EGFR, which contains a tyrosine kinase activity. The kinase transfers phosphate residues onto a flexible tail, which can subsequently recruit and activate downstream efectors like ras. Afatinib can prevent this activation by inserting into the active site of the kinase domain and ...
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Jun 20, 2018
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