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Cellular mechanisms of atherosclerosis1. Low-density lipoprotein (LDL) is retained in the vascular wall, where it is modified by oxidation.2. Oxidized LDL (oxLDL) stimulates endothelial cells to express adhesion molecules.3. This induces leukocyte adhesion and recruitment.4. Infiltrating monocytes differentiate into macrophages.5. Macrophages take up oxLDL and become foam cells.6. Dendritic cells and macrophages present antigens to T cells.7. Macrophage death, for example by apoptosis, creates a
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