We have finally arrived at the biggest stage in college basketball, the 2025 Final Four, and after an NCAA Tournament that started trending towards chalk from the earliest rounds, history has been made yet again with just the second-ever time with all four No.

The SportsLine Projection Model has revealed its picks for Cooper Flagg and the Duke Blue Devils vs. the Houston Cougars in the Final Four of the 2025 NCAA Tournament

SportsLine's top college basketball experts reveal their 2025 NCAA Tournament Final Four score predictions, national semifinal picks for Houston vs. Duke and Auburn vs. Florida

Think of the Final Four this way: Auburn ranks higher at KenPom than all but six teams from 1997-2024, yet it ranks fourth in this Final Four and has BetMGM's longest odds to win it all at +525. Auburn would have been the favorite in 21 of the past 27 tournaments, if KenPom was used to set the odds.

This year's March Madness Sweet 16 wraps up Friday with Houston vs. Purdue. Here are expert picks, predictions and how to watch the game:

What are Final Four odds now? What to know about Houston Cougars vs Duke Blue Devils point spread, moneyline, over/under for March Madness betting.

The pinnacle of college basketball features a historic Final Four April 5-7 in San Antonio. All four No. 1 seeds are also historic statistical leaders. The winners of Auburn vs. Florida and Houston vs.

While some have complained that the lack of upsets have made the 2025 NCAA tournament a little less interesting, what we're left with is all four No. 1 seeds in the Final Four for only the second time in history.