Successful research in targeted protein degradation depends not only on measurements at high sensitivity, speed and precision ...

Key Laboratory of Natural Products & Chemical Biology, Ministry of Education, Shandong University, Jinan 250012, P. R. China ...

Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur, Nadia, West Bengal 741246, India ...

U.S., and colleagues have designed and constructed a lysosome-targeted photoinduced pyroptosis and ferroptosis theranostic nanoplatform M@P by self-assembly of photosensitizer MTCN-3 and ...

The title should instead appear as “Hapalindole Q suppresses autophagosome−lysosome fusion by promoting YAP1 degradation via chaperone-mediated autophagy.” The legends for Figs. 1, 5, and 6 appeared ...

Fats and other cellular materials reach the lysosome through three main pathways: endocytosis, phagocytosis, and autophagy. In endocytosis, the cell takes in materials from outside by wrapping ...

Once fats are broken down in the lysosome, they serve several important roles in the cell. One is membrane repair and maintenance. The broken-down fat components, such as phospholipids and ...

Once fats are broken down in the lysosome, they serve several important roles in the cell. One is membrane repair and maintenance. The broken-down fat components, such as phospholipids and ...

In this study, the authors use the zebrafish to investigate how the microbiome affects a specialized gut cell called the lysosome rich enterocyte. They use a combination of functional assays for ...

Autophagosomes are double-membraned vesicles that contain cellular material slated to be degraded by autophagy. An isolation membrane or phagophore forms near autophagic cargo and expands until it ...

These mechanisms may serve as a checkpoint for the presence of the vacuole/lysosome. Animals, fungi and other eukaryotes have cells that are divided into sub-compartments that are called organelles.