EMBO Press

BACE1 regulates sleep–wake cycle through both enzymatic and non–enzymatic actions

A proteolytically inactive BACE1 knock-in (BACE1-KI, D289N) is compared with a BACE1 knockout (BACE1-KO) mouse to dissect ...
EMBO Press

From microscopes to maps: enabling a new era of open and reproducible data sharing in intravital imaging

In this issue of The EMBO Journal, Pizzagalli and colleagues present proof-of-principle analyses of immune cell motility ...
EMBO Press

NINJ1 blocks HSV-1 entry into macrophages to impact viral replication and immunity

NINJ1 blocks HSV-1 entry into mouse macrophages independent of its role in cell death, resulting in greater secretion of pro ...
EMBO Press

Evolutionary relaxation and functional change of INSL3 and RXFP2 may underlie natural cryptorchidism in mammals

This study examines how evolutionary relaxation and functional change of INSL3 and RXFP2 relate to natural cryptorchidism in ...
EMBO Press

Closing the loop on EGFR therapy: decoding cetuximab response through circ-EGFR

Over the past decade, several tumor-based predictors of cetuximab efficacy have been identified, yet most function as ...
The EMBO Journal

Predicting cellular responses to complex perturbations in high‐throughput screens

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The compositional perturbation autoencoder ...
The EMBO Journal

Optineurin provides a mitophagy contact site for TBK1 activation

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Tank-binding kinase 1 (TBK1) is a Ser/Thr ...
The EMBO Journal

Direct action of endocrine disrupting chemicals on human sperm

A plethora of endocrine disrupting chemicals (EDCs)—omnipresent in food, household, and personal care products—interfere with various human sperm functions and thus might impair fertilization.
The EMBO Journal

Gli1 labels progenitors during chondrogenesis in postnatal mice

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Gli1 + chondrogenic progenitors maintained by ...
The EMBO Journal

PerturbNet predicts single-cell responses to unseen chemical and genetic perturbations

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Chemical and genetic perturbations, such as ...
The EMBO Journal

ER-phagy restrains inflammatory responses through its receptor UBAC2

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. ER-phagy, a selective form of autophagic ...
The EMBO Journal

The HSP110/HSP70 disaggregation system generates spreading‐competent toxic α‐synuclein species

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The HSP110/HSP70 chaperone system plays key ...