Most drugs are metabolized by CYP3A enzymes, and variations in expression levels of these enzymes are believed to determine whether patients will have a positive or adverse drug response. Little is ...
Table 3 Number of tag SNPs identified by ldSelect to capture genetic diversity across the CYP3A locus (MAF=9%) Full size table Of the six regions containing predicted clusters of transcription factor ...
Oral erythromycin prolongs cardiac repolarization and is associated with case reports of torsades de pointes. Because erythromycin is extensively metabolized by cytochrome P-450 3A (CYP3A) isozymes, ...
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