Catholic cardinals will sequester themselves Wednesday behind the Vatican’s medieval walls for the start of a conclave to elect the 267th pontiff of the Roman Catholic Church, a successor to Pope Francis who died in April at the age of 88.

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When the conclave begins in the Sistine Chapel on Wednesday, everything will revolve around the successor to pope Francis. The focus will be on the cardinals, including some who are not considered candidates and are less well-known.