The discovery five years ago that short interfering RNAs (siRNAs) can also silence gene expression in higher organisms has revolutionized loss-of-function genetic screens in mammalian cells 1. The use ...
Cell therapy developer Celyad Oncology is using short-hairpin RNA (shRNA) to create T cells that can be used as an “off-the-shelf” allogeneic therapy for cancer patients. They are also using the ...
RNA interference is a biological process that has evolved with the evolution of mammals and plays an important role in transient and long-term blocking of protein expression. Short Hairpin RNA (shRNA) ...
RNA-based therapies are enjoying a renaissance, owing in part to the recent approvals of Alnylam Pharmaceuticals’ RNA interference (RNAi) drugs, Onpattro ® (patisiran) and Givlaari™ (givosiran).
A powerful algorithm that improves the effectiveness of an important research technology harnessing RNA interference, or RNAi, has been developed by scientists. Scientists at Cold Spring Harbor ...
Gene knockdown is a common method for studying gene function by reducing messenger ribonucleic acid (mRNA) levels without altering the deoxyribonucleic acid (DNA). Among the available techniques, RNA ...
Arterial stiffness to predict hypertensive response to antiangiogenic drugs. This is an ASCO Meeting Abstract from the 2013 ASCO Annual Meeting I. This abstract does not include a full text component.
Sigma-Aldrich has announced the release of the MISSION™ TRC shRNA human and mouse libraries for RNA interference-based research. The collection now carries approximately 65,000 shRNA vector constructs ...
Sigma, a division of Sigma-Aldrich Corporation, through an exclusive agreement with The RNAi Consortium (TRC), has announced the expansion of the MISSION TRC shRNA library product lines to include ...
GBU distributes clones from the TRC1 shRNA library and the Sanger CRISPR knockout gRNA library. The clones are available as glycerol stocks, plates, DNA minipreps or midipreps. If you need virus ...
If our TRC library does not cover the hairpin you need for your research, we can clone a custom sequence for you into the TRC library vector pLKO.1. Contact us by email if you wish to order custom ...
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