A rectal ulcer happens when one or more of the mucus layers that line the rectum are injured or damaged, resulting in a painful sore. Your rectum is the last few inches of your large intestine (colon) ...

What Is Proctitis and How Does It Compare to UC? Proctitis is inflammation of the rectum, the last part of the large intestine that connects the colon to the anus. Ulcerative colitis (UC) is a type of ...

Ulcerative colitis is a condition that affects your colon and rectum. Its symptoms vary based on how severe it is. They can range from mild cases with a few stomach cramps and constipation, to more ...

Ulcerative colitis causes bloody diarrhea, abdominal pain, and changes in bowel habits. UC flare-ups are worsened by stress, certain foods, and menstrual cycles. Other symptoms of UC include fever, ...

Ulcerative colitis can lead to changes in your stool's texture, color, and smell. You may notice increased bowel movement frequency, which can disrupt your daily life and sleep. Frequent diarrhea and ...

Mirikizumab, a p19-directed antibody against interleukin-23, showed efficacy in the treatment of ulcerative colitis in a phase 2 trial. We conducted two phase 3, randomized, double-blind, ...