Hdy-7 directly binds to TrxR1/2, triggering ROS accumulation and p53 activation. Activated p53 negatively regulates mTORC1 signaling, which is one of the major kinases responsible for the ...
Macrophages are the specialized phagocytic cells that respond to toxic particle depositions to exert inflammatory and clearance responses. These long-lived immune cells engulf foreign substances like ...
(A) The images show MLRO in primary cultured mouse hepatocytes. The bar scale is 500 nm. (B) The proposed model illustrates how lysosomes and TFEB regulate MLRO in hepatocyte dedifferentiation.
TFEB activity is tightly controlled by PTM-mediated nuclear translocation and signaling. Numerous studies have demonstrated beneficial effects of heterologous TFEB expression in rodent models of ...
Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...
Lysosomes are cellular waste disposal organelles containing potent enzymes. These enzymes can cause cellular damage if they leak out of ruptured lysosomes. In a recent study led by Osaka University, ...
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