Structural, functional and computational evidence demonstrates that when certain ion channels are activated by mechanical force, they assume an open configuration in which the pore is formed by both ...

A new imaging approach is shedding light on one of cell biology’s most elusive questions: how lipids are organized and sorted within membranes.

A new imaging technique reveals lipids in cellular membranes and shows how they are organized at the nanoscale.

A team at Helmholtz Munich and the Technical University of Munich (TUM) has developed a new microscopy technique that can ...

Researchers have captured the first cryo-electron microscopy snapshots of the cold-sensing ion channel TRPM8 in its open ...

Pharmaceutical scientists and biologists are teaming up to make the next generation of lipid nanoparticles (LNPs) for drug delivery. Combining structural biology with cutting edge pharmaceutical ...

Biological membranes of cells and their subunits (organelles) are organized into tiny regions (nanodomains) made up of fats ...

A research team led by Daniel Lietha has just published in The EMBO Journal the mechanistic details of the activation of the Focal Adhesion Kinase (FAK) on lipid membranes. Lietha started this ...

In humans, virtually every cell stores fat. However, patients with a rare condition called congenital lipodystrophy, which is often diagnosed in childhood, cannot properly store fat, which accumulates ...

Eight young (25.5 ± 1.0 years), healthy men were studied. They were lean (weight 76.4 ± 4.0 kg; BMI 25.4 ± 1.0 kg/m 2) and without any family history of diabetes. The study was approved by the Ethical ...

Penn Engineers have redesigned a key component of lipid nanoparticles (LNPs), the delivery vehicles behind mRNA vaccines, to ...