This constitutive KI mouse model was generated by Flp-mediated homologous recombination in mouse embryonic stem cells to introduce an S65A point mutation in exon 3 of the Park2 (Parkin) gene ...

Researchers studying the relationship between the kinase PINK1 and the ubiquitin ligase parkin have discovered that the two interact in a surprising way. Both PINK1 and parkin are risk factors for ...

Kinase enzymes such as PINK1 alter the behaviour of target proteins through the addition of phosphate groups, a process called phosphorylation. PINK1 is imported to mitochondria and, in healthy cells, ...

An international team of scientists led by the University of Dundee, UK have verified that a molecular pathway that has been studied for years under laboratory conditions, is also disrupted in ...

Researchers at the Faculty of Medicine, University of Helsinki, make an unexpected and vital contribution to an international collaborative effort in Parkinson's disease research. An international ...

Researchers have made an unexpected and vital contribution to an international collaborative effort in Parkinson's disease research. An international team of scientists led by the University of Dundee ...