Iowa State University researchers have described with single-molecule precision how copper ions cause prion proteins to misfold and seed the misfolding and clumping of nearby prion proteins. The ...
Scientists at Northwestern University and University of California, Santa Barbara have created the first synthetic fragment of tau protein that acts like a prion. The “mini prion” folds and stacks ...
The most common cause of inherited prion diseases is the E200K mutation of the prion protein (PrP). It is often thought that this mutation causes disease by making PrP more susceptible to misfolding ...
When proteins are made in a cell, they start out as strings of amino acids, which have to be folded into the correct, three-dimensional shape so they will function properly. Misfolded proteins can ...
An interdisciplinary team led by School of Engineering and Applied Science’s Lee C. Bassett and Dani Bassett, also of the School of Arts & Sciences, have studied the mechanical properties of prions, ...
An error in protein conformation can lead to disease. What are the genetic and molecular causes for incorrectly formed proteins? molecules. In 1917 the German chemist ...
Durable analytical instruments expedite the study of misfolded proteins linked to neurodegenerative diseases. To overcome these limitations, scientists developed the real-time quaking-induced ...
The first synthetic fragment of tau protein has been created, revealing more about the diagnosis and treatment of neurodegenerative diseases. Researchers at Northwestern University (IL, USA) and the ...
All mammals produce a version of the prion protein, but scientists don’t know what it normally does. In an altered form, the prion protein becomes an infectious agent that causes “mad cow disease” and ...
When proteins misfold, accumulate and clump around insulin-producing cells in the pancreas, they kill cells. Now, researchers, including University of Michigan biophysicists, have obtained a ...
The brain of a rat in which a fluorescent protein has been used to highlight transplanted human brain cells - Copyright Stanford University/AFP Sergiu PASCA The brain ...
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