We went 4-1 straight up on our top five picks, but 1-4 against the spread. The Baltimore Ravens defeated the Cincinnati Bengals by a single point, the San Francisco 49ers struggled with the Tampa Bay ...

You want upsets? We've got upsets. Multiple underdogs defeated the favorite in Week 10 of the 2025 NFL season. Continue reading to find a complete list of the teams that defied the odds. Read more ...