Understanding a drug’s mechanism of action (MOA) can greatly increase the likelihood of successful clinical trials by identifying biomarkers of patient response and providing a rationale for ...

* Halicin discovered using AI shows potent activity against multidrug-resistant bacteria * Unconventional mechanism targets proton motive force, limiting bacterial //resistance * Preclinical results ...

Bacteria modify their ribosomes when exposed to widely used antibiotics, according to research published in Nature Communications. The subtle changes might be enough to alter the binding site of drug ...

A small molecule shaped like a lasso may be a powerful tool in the fight against infectious diseases. A small molecule shaped like a lasso may be a powerful tool in the fight against infectious ...

Lariocidin hits drug-resistant bacteria where others fail — by hijacking the ribosome at a new site, bypassing defences, and opening the door to a new generation of antibiotics. Lariocidin, a ...