Infants born with Down syndrome, the genetic condition caused by an extra copy of chromosome 21, or trisomy 21, are highly predisposed to congenital heart defects. It is estimated that nearly half of ...

Researchers have identified a suite of genes and regulatory elements critical to normal heart development. Their study outlines the importance of 'hub genes' in heart development. The advent of genome ...

Writing in Science Advances researchers of the University of Cologne describe a key mechanism that controls the decision-making process that allows human embryonic stem cells to make the heart. These ...

Men and women are not born with the same risk of heart disease, and for decades scientists have struggled to explain why. A ...

A team has induced stem cells to emulate the development of the human heart. The result is a sort of 'mini-heart' known as an organoid. It will permit the study of the earliest development phase of ...

Heart disease kills 18 million people each year, but the development of new therapies faces a bottleneck: no physiological model of the entire human heart exists – so far. A new multi-chamber organoid ...

A crucial new mechanism that helps explain how the heart’s major blood vessels form during early development – and how disruptions to this process can lead to serious congenital heart defects – has ...

Scientists at the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences have developed a multi-chamber organoid that mirrors the heart’s intricate structure. The human ...

A lab in Vienna has used stem cells to create thousands of tiny heart-like structures. Each miniature heart, dubbed a “cardioid,” is the size of a sesame-seed and has a hollow chamber that beats.

New research in Sweden has produced a "blueprint" revealing how the human heart is built during prenatal development. It offers insights that could lead to improved prenatal care and new treatments ...

A hole in the heart is a nonmedical term for a type of congenital heart defect. There are many types of holes in the heart, and most are present from birth. Around 1% of babies born in the United ...